LILRA3

Leukocyte immunoglobulin-like receptor subfamily A member 3 (LILR-A3) also known as CD85 antigen-like family member E (CD85e), immunoglobulin-like transcript 6 (ILT-6), and leukocyte immunoglobulin-like receptor 4 (LIR-4) is a protein that in humans is encoded by the LILRA3 gene located within the leukocyte receptor complex on chromosome 19q13.4. Unlike many of its family, LILRA3 lacks a transmembrane domain. The function of LILRA3 is currently unknown; however, it is highly homologous to other LILR genes,^[2] and can bind human leukocyte antigen (HLA) class I. Therefore, if secreted, the LILRA3 might impair interactions of membrane-bound LILRs (such as LILRB1, an inhibitory receptor expressed on effector and memory CD8 T cells) with their HLA ligands, thus modulating immune reactions and influencing susceptibility to disease.^[3][4][5]

PDBHuman UniProt search: PDBe RCSB

AliasesLILRA3, CD85E, HM31, HM43, ILT-6, ILT6, LIR-4, LIR4, leukocyte immunoglobulin like receptor A3

External IDsOMIM: 604818; GeneCards: LILRA3; OMA:LILRA3 - orthologs

Bgee

Human	Mouse (ortholog)
n/a	n/a

Quick facts Available structures, PDB ...

LILRA3
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 3Q2C
Identifiers
Aliases	LILRA3, CD85E, HM31, HM43, ILT-6, ILT6, LIR-4, LIR4, leukocyte immunoglobulin like receptor A3
External IDs	OMIM: 604818; GeneCards: LILRA3; OMA:LILRA3 - orthologs
RNA expression pattern Bgee Human Mouse (ortholog) n/a n/a BioGPS More reference expression data
Gene ontology Molecular function antigen binding signaling receptor activity Cellular component extracellular region plasma membrane specific granule membrane tertiary granule membrane ficolin-1-rich granule membrane Biological process defense response adaptive immune response signal transduction immune system process neutrophil degranulation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11026 n/a Ensembl n/a n/a UniProt Q8N6C8 n/a RefSeq (mRNA) NM_001172654 NM_006865 n/a RefSeq (protein) NP_001166125 NP_006856 n/a Location (UCSC) n/a n/a PubMed search [1] n/a
Wikidata
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Like the closely related LILRA1, LILRA3 binds to both normal and 'unfolded' free heavy chains of HLA class I, with a preference for free heavy chains of HLA-C alleles ^[6]