LITAF

Lipopolysaccharide-induced tumor necrosis factor-alpha factor is a protein that in humans is encoded by the LITAF gene.^[5][6][7]

AliasesLITAF, PIG7, SIMPLE, TP53I7, lipopolysaccharide induced TNF factor

External IDsOMIM: 603795; MGI: 1929512; GeneCards: LITAF

Chr.Chromosome 16 (human)^[1]

End11,636,381 bp^[1]

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LITAF
Identifiers
Aliases	LITAF, PIG7, SIMPLE, TP53I7, lipopolysaccharide induced TNF factor
External IDs	OMIM: 603795; MGI: 1929512; GeneCards: LITAF
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p13.13 Start 11,547,722 bp[1] End 11,636,381 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16|16 A1 Start 10,777,139 bp[2] End 10,884,021 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in blood palpebral conjunctiva periodontal fiber visceral pleura mucosa of urinary bladder appendix tibia granulocyte canal of the cervix gallbladder Top expressed in granulocyte endothelial cell of lymphatic vessel stroma of bone marrow blood decidua vestibular sensory epithelium left colon gastrula vestibular membrane of cochlear duct skin of external ear More reference expression data BioGPS More reference expression data
Gene ontology Molecular function signal transducer activity protein binding WW domain binding zinc ion binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA binding metal ion binding Cellular component membrane nucleoplasm lysosomal membrane lysosome cytosol cytoplasmic side of plasma membrane cytoplasmic side of early endosome membrane cytoplasmic side of late endosome membrane cytoplasmic side of lysosomal membrane Golgi membrane nucleus cytoplasm endosome Golgi apparatus plasma membrane endosome membrane early endosome membrane late endosome membrane intracellular membrane-bounded organelle integral component of membrane Biological process regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II ageing transcription, DNA-templated regulation of cytokine production response to lipopolysaccharide positive regulation of I-kappaB kinase/NF-kappaB signaling cellular response to lipopolysaccharide signal transduction transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 9516 56722 Ensembl ENSG00000189067 ENSMUSG00000022500 UniProt Q99732 Q9JLJ0 RefSeq (mRNA) NM_001136472 NM_001136473 NM_004862 NM_019980 RefSeq (protein) NP_001129944 NP_001129945 NP_004853 NP_064364 Location (UCSC) Chr 16: 11.55 – 11.64 Mb Chr 16: 10.78 – 10.88 Mb PubMed search [3] [4]
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It is associated with Charcot–Marie–Tooth disease 1C.