LRSAM1

LRSAM1
Identifiers
Aliases	LRSAM1, CMT2P, RIFLE, TAL, leucine rich repeat and sterile alpha motif containing 1
External IDs	OMIM: 610933; MGI: 2684789; HomoloGene: 44526; GeneCards: LRSAM1; OMA:LRSAM1 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	127,503,499 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	32,851,626 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; sural nerve; ; skin of leg; ; skin of abdomen; ; left ventricle; ; right hemisphere of cerebellum; ; right frontal lobe; ; muscle layer of sigmoid colon; ; anterior cingulate cortex; ; Brodmann area 9;
	Top expressed in
	hypothalamus; ; granulocyte; ; placenta; ; white adipose tissue; ; neural layer of retina; ; cerebellar cortex; ; quadriceps femoris muscle; ; skeletal muscle tissue; ; olfactory bulb; ; mesencephalon;
	More reference expression data
	n/a
Gene ontology
Molecular function	ubiquitin protein ligase activity; metal ion binding; ubiquitin-protein transferase activity; protein binding; transferase activity; volume-sensitive anion channel activity;
Cellular component	cytoplasm; membrane; cytosol; plasma membrane; ion channel complex;
Biological process	negative regulation of endocytosis; positive regulation of autophagosome assembly; protein polyubiquitination; positive regulation of xenophagy; viral budding; autophagy; protein catabolic process; protein ubiquitination; protein transport; ubiquitin-dependent endocytosis; protein autoubiquitination; signal transduction; anion transmembrane transport; inorganic anion transport;
	Sources:Amigo / QuickGO
Orthologs
	90678
	227738
	ENSG00000148356
	ENSMUSG00000026792
	Q6UWE0
	Q80ZI6
NM_001005373; NM_001005374; NM_001190723; NM_138361; NM_001384142;
	NM_001384143; NM_001384144
NM_199302; NM_001379439; NM_001379440; NM_001379441; NM_001379442;
	NM_001379443
NP_001005373; NP_001005374; NP_001177652; NP_612370; NP_001371071;
	NP_001371072; NP_001371073
NP_955006; NP_001366368; NP_001366369; NP_001366370; NP_001366371;
	NP_001366372
	Wikidata
View/Edit Human	View/Edit Mouse

E3 ubiquitin-protein ligase LRSAM1, previously known as Tsg101-associated ligase (Tal), is an enzyme that in humans is encoded by the LRSAM1 gene.^[5]^[6]