LSP1

Lymphocyte-specific protein 1 is a protein that in humans is encoded by the LSP1 gene.^[5][6]

PDBOrtholog search: PDBe RCSB

AliasesLSP1, WP34, pp52, lymphocyte-specific protein 1, lymphocyte specific protein 1

External IDsOMIM: 153432; MGI: 96832; HomoloGene: 1750; GeneCards: LSP1; OMA:LSP1 - orthologs

Chr.Chromosome 11 (human)^[1]

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LSP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3BH8, 4NO0, 4NO2
Identifiers
Aliases	LSP1, WP34, pp52, lymphocyte-specific protein 1, lymphocyte specific protein 1
External IDs	OMIM: 153432; MGI: 96832; HomoloGene: 1750; GeneCards: LSP1; OMA:LSP1 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p15.5 Start 1,850,904 bp[1] End 1,892,267 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 F5|7 87.93 cM Start 142,014,546 bp[2] End 142,048,604 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte blood monocyte spleen appendix bone marrow cell right adrenal cortex lymph node left adrenal gland left adrenal cortex Top expressed in granulocyte thymus mesenteric lymph nodes tibiofemoral joint vas deferens spleen uterus lip efferent ductule blood More reference expression data BioGPS More reference expression data
Gene ontology Molecular function actin binding signal transducer activity Cellular component extracellular exosome actin cytoskeleton membrane plasma membrane Biological process chemotaxis cellular defense response defense response signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4046 16985 Ensembl ENSG00000130592 ENSG00000288199 ENSMUSG00000018819 UniProt P33241 P19973 RefSeq (mRNA) NM_002339 NM_001013253 NM_001013254 NM_001013255 NM_001242932 NM_001289005 NM_001136071 NM_001271508 NM_001271509 NM_001271510 NM_001271523 NM_019391 RefSeq (protein) NP_001013271 NP_001013272 NP_001013273 NP_001229861 NP_001275934 NP_002330 NP_001129543 NP_001258437 NP_001258438 NP_001258439 NP_001258452 NP_062264 Location (UCSC) Chr 11: 1.85 – 1.89 Mb Chr 7: 142.01 – 142.05 Mb PubMed search [3] [4]
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This gene encodes an intracellular F-actin binding protein. The protein is expressed in lymphocytes, neutrophils, macrophages, and endothelium and may regulate neutrophil motility, adhesion to fibrinogen matrix proteins, and transendothelial migration. Alternative splicing results in multiple transcript variants encoding different isoforms.^[6]