LYPD1

Ly6/PLAUR domain-containing protein 1 is a protein that in humans is encoded by the LYPD1 gene.^[5][6]

AliasesLYPD1, LYPDC1, PHTS, LY6/PLAUR domain containing 1

External IDsOMIM: 610450; MGI: 1919835; HomoloGene: 16937; GeneCards: LYPD1; OMA:LYPD1 - orthologs

Chr.Chromosome 2 (human)^[1]

End132,671,579 bp^[1]

Quick facts Identifiers, Aliases ...

LYPD1
Identifiers
Aliases	LYPD1, LYPDC1, PHTS, LY6/PLAUR domain containing 1
External IDs	OMIM: 610450; MGI: 1919835; HomoloGene: 16937; GeneCards: LYPD1; OMA:LYPD1 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q21.2 Start 132,643,286 bp[1] End 132,671,579 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 E3 Start 125,795,359 bp[2] End 125,840,838 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube nucleus accumbens caudate nucleus putamen ventricular zone hypothalamus amygdala pituitary gland cingulate gyrus anterior cingulate cortex Top expressed in glossopharyngeal ganglion ganglion of vagus nerve dentate gyrus of hippocampal formation granule cell cuneiform bones cranial nervi inferior ganglion of vagus nerve amygdala olfactory nerve primary visual cortex superior frontal gyrus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function acetylcholine receptor binding acetylcholine receptor inhibitor activity Cellular component membrane anchored component of membrane extracellular region plasma membrane Biological process response to nicotine behavioral fear response negative regulation of signaling receptor activity synaptic transmission, cholinergic cell activation acetylcholine receptor signaling pathway negative regulation of protein localization to plasma membrane Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 116372 72585 Ensembl ENSG00000150551 ENSMUSG00000026344 UniProt Q8N2G4 Q8BLC3 RefSeq (mRNA) NM_001077427 NM_144586 NM_001321234 NM_001321235 NM_145100 NM_001311089 NM_001311090 RefSeq (protein) NP_001070895 NP_001308163 NP_001308164 NP_653187 NP_001298018 NP_001298019 NP_659568 Location (UCSC) Chr 2: 132.64 – 132.67 Mb Chr 1: 125.8 – 125.84 Mb PubMed search [3] [4]
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This protein is also known as Lynx2, a member of the Lynx family of neurotransmitter receptor-binding proteins.^[7] Transgenic mice without Lynx2 expression have increased anxiety-related behaviors.^[8]