Lesopitron

Lesopitron
Clinical data
Routes of; administration	Oral
ATC code	none;
Legal status
Legal status	In general: uncontrolled;
Identifiers
	IUPAC name 2-{4-[4-(4-chloro-1H-pyrazol-1-yl)butyl]piperazin-1-yl}pyrimidine;
CAS Number	132449-46-8;
PubChem CID	60813;
ChemSpider	54801;
UNII	H1CGM4755H;
CompTox Dashboard (EPA)	DTXSID40157587 ;
Chemical and physical data
Formula	C15H21ClN6
Molar mass	320.83 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Clc1cn(nc1)CCCCN3CCN(c2ncccn2)CC3;

Lesopitron (E-4424) is a selective full agonist of the 5-HT_1A receptor which is structurally related to the azapirones.^[1] In 2001 it was under development by Esteve as an anxiolytic for the treatment of generalized anxiety disorder (GAD).^[2]^[3] It made it to phase II clinical trials but was apparently discontinued as no new information on lesopitron has surfaced since.^[2]^[3]

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Clinical data

Routes of administration	Oral
ATC code	none
Legal status
Legal status	In general: uncontrolled
Identifiers
IUPAC name 2-{4-[4-(4-chloro-1H-pyrazol-1-yl)butyl]piperazin-1-yl}pyrimidine
CAS Number	132449-46-8
PubChem CID	60813
ChemSpider	54801
UNII	H1CGM4755H
CompTox Dashboard (EPA)	DTXSID40157587
Chemical and physical data
Formula	C₁₅H₂₁ClN₆
Molar mass	320.83 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES Clc1cn(nc1)CCCCN3CCN(c2ncccn2)CC3