Mesalazine
Anti-inflammatory medication
From Wikipedia, the free encyclopedia
Mesalazine, also known as mesalamine or 5-aminosalicylic acid (5-ASA), is a medication used to treat inflammatory bowel disease, including ulcerative colitis and Crohn's disease.[1] It is generally used for mildly to moderately severe disease.[1] It is taken by mouth or rectally.[1] The formulations which are taken by mouth appear to be similarly effective.[12]
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 Above: molecular structure of mesalazine
Below: 3D representation of a mesalazine molecule | |
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| Trade names | Asacol, Lialda, Pentasa, Delzicol, others[1] |
| Other names | Mesalamine, 5-aminosalicylic acid, 5-ASA, Mesalamine (USAN US) |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a688021 |
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| Routes of administration | By mouth, rectal |
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| Bioavailability | Oral: 20–30% Rectal: 10–35% |
| Metabolism | Rapidly and extensively metabolized intestinal mucosal wall and the liver |
| Elimination half-life | 5 hours after initial dose. At steady state 7 hours |
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| ECHA InfoCard | 100.001.745 |
| Chemical and physical data | |
| Formula | C7H7NO3 |
| Molar mass | 153.137 g·mol−1 |
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| Melting point | 283 °C (541 °F) |
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Common side effects include headache, nausea, abdominal pain, and fever.[1] Serious side effects may include pericarditis, liver problems, and kidney problems.[1][12] Use in pregnancy and breastfeeding appears safe.[12] In people with a sulfa allergy certain formulations may result in problems.[1] Mesalazine is an aminosalicylate and anti-inflammatory.[1][12] It works by direct contact with the intestines.[1]
Mesalazine was approved for medical use in the United States in 1987.[1][8] It is on the World Health Organization's List of Essential Medicines.[13] It is available as a generic medication.[1][14][15][16] In 2023, it was the 202nd most commonly prescribed medication in the United States, with more than 2 million prescriptions.[17][18]
Medical uses
It is used to treat inflammatory bowel disease, including ulcerative colitis and Crohn's disease (effective only in colonic diseases).[1]
In 2022 Germany introduced guidance to use mesalamine to treat acute uncomplicated diverticulitis.[19]
Side effects
Most often reported side effects are headache, nausea, diarrhea, and abdominal pain.[7]
Very rarely, use of mesalazine has been associated with an exacerbation of the symptoms of colitis, Stevens–Johnson syndrome, and erythema multiforme.[7]
Pregnancy
There is no data on use in pregnant women, but the drug does cross the placenta and is excreted in breast milk. The drug should not be used in children under two years of age,[7] people with kidney disease,[7] or people who are allergic to aspirin.[7]
Mechanism of action
The exact mechanism of mesalazine is unknown, but it is speculated that mesalazine decreases synthesis of prostaglandin and leukotriene, modulating the inflammatory response derived from the cyclooxygenase and lipooxygenase pathways.[20] It appears to act locally on colonic mucosa.[21] In 2025, mesalazine was reported to bind tubulin and stabilize microtubules.[22]
Chemistry
Mesalazine is an active metabolite of sulfasalazine, which is metabolized to sulfapyridine and mesalazine.[23] It is also the active metabolite of the prodrugs balsalazide (accompanied by the inert carrier molecule 4-aminobenzoyl-β-alanine[24]) and olsalazine (which is metabolized to two equivalents of mesalazine). It is in the category of disease-modifying antirheumatic drugs (DMARDs) family of medications.[25] It is unclear exactly how it works.[25] Mesalazine is claimed to be a PPAR-γ agonist.[26]
Mesalazine has application in the synthesis of Crisdesalazine, Fendosal [53597-27-6] & Parsalmide [30653-83-9].
