Limulus clotting factor B

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Limulus clotting factor B (EC 3.4.21.85) is an enzyme.[1] This enzyme catalyses the following chemical reaction:

Selective cleavage of -Arg98-Ile99- bond in limulus proclotting enzyme to form active clotting enzyme

This enzyme is present in the hemocyte granules of the horseshoe crabs Limulus and Tachypleus. In the immunity-related clotting pathways of these organisms, factor B is downstream of Limulus clotting factor C, but upstream of Limulus clotting enzyme.[2]

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