Amlodipine/benazepril
Antihypertensive medication
From Wikipedia, the free encyclopedia
Amlodipine/benazepril, sold under the brand name Lotrel among others, is a fixed-dose combination medication used to treat high blood pressure.[1] It is a combination of amlodipine, as the besilate, a calcium channel blocker, and benazepril, an angiotensin converting enzyme inhibitor.[1] It may be used if a single agent is not sufficient.[1] It is taken by mouth.[1]
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| Combination of | |
|---|---|
| Amlodipine | Calcium channel blocker |
| Benazepril | ACE inhibitor |
| Clinical data | |
| Trade names | Lotrel |
| AHFS/Drugs.com | Professional Drug Facts |
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| Routes of administration | By mouth |
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Common side effects include cough, dizziness, and swelling.[1] Serious side effects may include angioedema, myocardial infarction, high blood potassium, liver problems, and low blood pressure.[1] Use in pregnancy is not recommended.[1] Amlodipine works by increasing the size of arteries while benazepril works by decreasing renin-angiotensin-aldosterone system activity.[1]
The combination was approved for medical use in the United States in 1995.[2] It is available as a generic medication.[3] In 2023, it was the 186th most commonly prescribed medication in the United States, with more than 2 million prescriptions.[4][5]
Medical uses
It is used to treat high blood pressure.[1] It is not a first-line treatment.[6]
