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Luigi Sepiacci, O.E.S.A. (12 September 1835 – 26 April 1893) – born Domenico Daniele Sepiacci – was an Italian prelate of the Catholic Church who held senior positions in the Roman Curia from 1886 until his death. He was made a cardinal in 1891. He previously led the Order of Saint Augustine, headed the academy where the Holy See trains its diplomats, and led the Diocese of Perugia.