MAGEA1

Melanoma-associated antigen 1 is a protein that in humans is encoded by the MAGEA1 gene.^[3]

PDBHuman UniProt search: PDBe RCSB

AliasesMAGEA1, CT1.1, MAGE1, MAGE family member A1

External IDsOMIM: 300016; HomoloGene: 88717; GeneCards: MAGEA1; OMA:MAGEA1 - orthologs

Chr.X chromosome (human)^[1]

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MAGEA1
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1W72, 3BO8
Identifiers
Aliases	MAGEA1, CT1.1, MAGE1, MAGE family member A1
External IDs	OMIM: 300016; HomoloGene: 88717; GeneCards: MAGEA1; OMA:MAGEA1 - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xq28 Start 153,179,284 bp[1] End 153,183,880 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad testicle right testis left testis urinary bladder human musculoskeletal system kidney muscular system muscle renal cortex n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function histone deacetylase binding protein binding Cellular component cytoplasm plasma membrane nucleus Biological process regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II transcription, DNA-templated negative regulation of Notch signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4100 n/a Ensembl ENSG00000198681 n/a UniProt P43355 n/a RefSeq (mRNA) NM_004988 n/a RefSeq (protein) NP_004979 n/a Location (UCSC) Chr X: 153.18 – 153.18 Mb n/a PubMed search [2] n/a
Wikidata
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This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita.^[4]