MAM domain

MAM domain is an evolutionary conserved protein domain. It is an extracellular domain found in many receptors.

A 170 amino acid domain, the so-called MAM (meprin, A-5 protein, and receptor protein-tyrosine phosphatase mu) domain, has been recognised in the extracellular region of functionally diverse proteins.^[1] These proteins have a modular, receptor-like architecture comprising a signal peptide, an N-terminal extracellular domain, a single transmembrane domain and an intracellular domain. Such proteins include meprin (a cell surface glycoprotein);^[2] A5 antigen (a developmentally-regulated cell surface protein; Xenopus nrp1; P28824);^[3] and receptor-like tyrosine protein phosphatase.^[4] The MAM domain is thought to have an adhesive function. It contains 4 conserved cysteine residues, which probably form disulphide bridges.