MAN2A1

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

Alpha-mannosidase 2 is an enzyme that in humans is encoded by the MAN2A1 gene.[5][6][7]

AliasesMAN2A1, AMan II, GOLIM7, MANA2, MANII, mannosidase alpha class 2A member 1
End109,869,625 bp[1]
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MAN2A1
Identifiers
AliasesMAN2A1, AMan II, GOLIM7, MANA2, MANII, mannosidase alpha class 2A member 1
External IDsOMIM: 154582; MGI: 104669; HomoloGene: 1777; GeneCards: MAN2A1; OMA:MAN2A1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002372

NM_008549

RefSeq (protein)

NP_002363

NP_032575

Location (UCSC)Chr 5: 109.69 – 109.87 MbChr 17: 64.91 – 65.06 Mb
PubMed search[3][4]
Wikidata
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Function

This gene encodes a protein which is a member of family 38 of the glycosyl hydrolases. The protein is located in the Golgi apparatus and catalyzes the final hydrolytic step in the asparagine-linked oligosaccharide (N-linked glycosylation) maturation pathway. Mutations in the mouse homolog of this gene have been shown to cause a systemic autoimmune disease similar to human systemic lupus erythematosus.[7]

References

Further reading

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