MAP1LC3A
Protein-coding gene in the species Homo sapiens
From Wikipedia, the free encyclopedia
Microtubule-associated proteins 1A/1B light chain 3A is a protein that in humans is encoded by the MAP1LC3A gene.[5][6][7] Two transcript variants encoding different isoforms have been found for this gene.
| MAP1LC3A | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Aliases | MAP1LC3A, ATG8E, LC3, LC3A, MAP1ALC3, MAP1BLC3, microtubule associated protein 1 light chain 3 alpha | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 601242; MGI: 1915661; HomoloGene: 12021; GeneCards: MAP1LC3A; OMA:MAP1LC3A - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Function
MAP1A and MAP1B are microtubule-associated proteins which mediate the physical interactions between microtubules and components of the cytoskeleton. MAP1A and MAP1B each consist of a heavy chain subunit and multiple light chain subunits. The protein encoded by this gene is one of the light chain subunits and can associate with either MAP1A or MAP1B.[7]
MAPLC3A is one of the mammalian homologues of yeast ATG8, an important marker and effector of autophagy.[8]
Regulation
MAP1LC3A is regulated by several post-translational modifications. These include covalent linkage of the C-terminus to phosphatidylethanolamine in autophagic membranes, and phosphorylation by protein kinase A,[9] which downregulates its autophagy functions. Noncovalent interactions are important for its cargo targeting functions in selective autophagy. For example, it has been shown to interact with sequestosome 1.[10]
