MAPK4

Mitogen-activated protein kinase 4 is an enzyme that in humans is encoded by the MAPK4 gene.^[5][6]

AliasesMAPK4, ERK-4, ERK4, PRKM4, p63-MAPK, p63MAPK, mitogen-activated protein kinase 4

External IDsOMIM: 176949; MGI: 2444559; HomoloGene: 2058; GeneCards: MAPK4; OMA:MAPK4 - orthologs

Chr.Chromosome 18 (human)^[1]

End50,731,826 bp^[1]

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MAPK4
Identifiers
Aliases	MAPK4, ERK-4, ERK4, PRKM4, p63-MAPK, p63MAPK, mitogen-activated protein kinase 4
External IDs	OMIM: 176949; MGI: 2444559; HomoloGene: 2058; GeneCards: MAPK4; OMA:MAPK4 - orthologs
Gene location (Human) Chr. Chromosome 18 (human)[1] Band 18q21.1-q21.2 Start 50,560,087 bp[1] End 50,731,826 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18|18 E2 Start 73,928,486 bp[2] End 74,065,359 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in caudate nucleus nucleus accumbens right frontal lobe anterior cingulate cortex putamen right adrenal cortex right hemisphere of cerebellum left adrenal cortex amygdala prefrontal cortex Top expressed in olfactory tubercle habenula visual cortex Epithelium of choroid plexus superior frontal gyrus primary visual cortex primary motor cortex prefrontal cortex globus pallidus cingulate gyrus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein serine/threonine kinase activity ATP binding kinase activity protein heterodimerization activity nucleotide binding protein kinase binding protein homodimerization activity protein kinase activity transferase activity protein binding MAP kinase activity Cellular component cytosol nucleoplasm nucleus cytoplasm Biological process protein phosphorylation cell cycle phosphorylation MAPK cascade regulation of gene expression cellular response to organic substance intracellular signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5596 225724 Ensembl ENSG00000141639 ENSG00000282110 ENSMUSG00000024558 UniProt P31152 Q6P5G0 RefSeq (mRNA) NM_001292039 NM_001292040 NM_002747 NM_172632 NM_001360936 RefSeq (protein) NP_001278968 NP_001278969 NP_002738 NP_766220 NP_001347865 Location (UCSC) Chr 18: 50.56 – 50.73 Mb Chr 18: 73.93 – 74.07 Mb PubMed search [3] [4]
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Mitogen-activated protein kinase 4 is a member of the mitogen-activated protein kinase family. Tyrosine kinase growth factor receptors activate mitogen-activated protein kinases which then translocate into the nucleus where it phosphorylates nuclear targets.^[6]

The Arabidopsis MAPK4 is important in signalling ^[7]

Mechanistically, MAPK4 directly bound and activated AKT by phosphorylation of the activation loop at threonine 308. It also activated mTORC2 to phosphorylate AKT at serine 473 for full activation. MAPK4 overexpression induced oncogenic outcomes, including transforming prostate epithelial cells into anchorage-independent growth, and MAPK4 knockdown inhibited cancer cell proliferation, anchorage-independent growth, and xenograft growth.^[8]