MAPKAP1

Target of rapamycin complex 2 subunit MAPKAP1 is a protein that in humans is encoded by the MAPKAP1 gene.^[5][6] As the name indicates, it is a subunit of mTOR complex 2.

PDBOrtholog search: PDBe RCSB

AliasesMAPKAP1, JC310, MIP1, SIN1, SIN1b, SIN1g, mitogen-activated protein kinase associated protein 1, MAPK associated protein 1

External IDsOMIM: 610558; MGI: 2444554; HomoloGene: 11473; GeneCards: MAPKAP1; OMA:MAPKAP1 - orthologs

Chr.Chromosome 9 (human)^[1]

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MAPKAP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3VOQ
Identifiers
Aliases	MAPKAP1, JC310, MIP1, SIN1, SIN1b, SIN1g, mitogen-activated protein kinase associated protein 1, MAPK associated protein 1
External IDs	OMIM: 610558; MGI: 2444554; HomoloGene: 11473; GeneCards: MAPKAP1; OMA:MAPKAP1 - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q33.3 Start 125,437,393 bp[1] End 125,707,234 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 B Start 34,406,771 bp[2] End 34,624,950 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in muscle of thigh apex of heart stromal cell of endometrium oocyte gastrocnemius muscle secondary oocyte right auricle of heart left adrenal cortex left ventricle right adrenal cortex Top expressed in zygote genital tubercle secondary oocyte tail of embryo spermatocyte muscle of thigh ventricular zone interventricular septum epithelium of lens spermatid More reference expression data BioGPS More reference expression data
Gene ontology Molecular function phosphatidylinositol-3,5-bisphosphate binding phosphatidylinositol-3,4-bisphosphate binding phosphatidic acid binding protein binding phosphatidylinositol-4,5-bisphosphate binding protein kinase binding phosphatidylinositol-3,4,5-trisphosphate binding Cellular component Golgi apparatus membrane plasma membrane nucleoplasm cytoplasmic vesicle nucleus cytosol TORC2 complex cytoplasm Biological process substantia nigra development negative regulation of Ras protein signal transduction establishment or maintenance of actin cytoskeleton polarity stress-activated protein kinase signaling cascade TORC2 signaling activation of protein kinase B activity positive regulation of peptidyl-serine phosphorylation regulation of cellular response to oxidative stress Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 79109 227743 Ensembl ENSG00000119487 ENSMUSG00000038696 UniProt Q9BPZ7 Q8BKH7 RefSeq (mRNA) NM_001006617 NM_001006618 NM_001006619 NM_001006620 NM_001006621 NM_024117 NM_001290625 NM_001290626 NM_177345 NM_001362919 NM_001362920 NM_001362921 RefSeq (protein) NP_001006618 NP_001006619 NP_001006620 NP_001006621 NP_001006622 NP_077022 NP_001277554 NP_001277555 NP_796319 NP_001349848 NP_001349849 NP_001349850 Location (UCSC) Chr 9: 125.44 – 125.71 Mb Chr 2: 34.41 – 34.62 Mb PubMed search [3] [4]
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This gene encodes a protein that is highly similar to the yeast SIN1 protein, a stress-activated protein kinase. Alternatively spliced transcript variants encoding distinct isoforms have been described. Alternate polyadenylation sites as well as alternate 3' UTRs have been identified for transcripts of this gene.^[6]