MCF2L

Guanine nucleotide exchange factor DBS is a protein that in humans is encoded by the MCF2L gene.^[5][6]

PDBOrtholog search: PDBe RCSB

AliasesMCF2L, ARHGEF14, DBS, OST, MCF.2 cell line derived transforming sequence like

External IDsOMIM: 609499; MGI: 103263; HomoloGene: 11804; GeneCards: MCF2L; OMA:MCF2L - orthologs

Chr.Chromosome 13 (human)^[1]

Quick facts Available structures, PDB ...

MCF2L
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1KZ7, 1KZG, 1LB1, 1RJ2
Identifiers
Aliases	MCF2L, ARHGEF14, DBS, OST, MCF.2 cell line derived transforming sequence like
External IDs	OMIM: 609499; MGI: 103263; HomoloGene: 11804; GeneCards: MCF2L; OMA:MCF2L - orthologs
Gene location (Human) Chr. Chromosome 13 (human)[1] Band 13q34 Start 112,894,378 bp[1] End 113,099,742 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 A1.1 Start 12,873,806 bp[2] End 13,020,905 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum right frontal lobe paraflocculus of cerebellum pituitary gland apex of heart anterior pituitary C1 segment Brodmann area 9 prefrontal cortex primary visual cortex Top expressed in olfactory epithelium neural layer of retina cerebellar cortex primary visual cortex superior frontal gyrus dentate gyrus of hippocampal formation granule cell pituitary gland lobe of cerebellum cerebellar vermis islet of Langerhans More reference expression data BioGPS More reference expression data
Gene ontology Molecular function phosphatidylinositol binding lipid binding guanyl-nucleotide exchange factor activity Cellular component cytoplasm extrinsic component of cytoplasmic side of plasma membrane cytosol plasma membrane membrane endomembrane system extracellular space Biological process positive regulation of Rho protein signal transduction regulation of Rho protein signal transduction intracellular signal transduction regulation of small GTPase mediated signal transduction positive regulation of apoptotic process G protein-coupled receptor signaling pathway regulation of molecular function Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23263 17207 Ensembl ENSG00000126217 ENSMUSG00000031442 UniProt O15068 Q64096 RefSeq (mRNA) NM_001112732 NM_024979 NM_001320815 NM_001320816 NM_001320817 NM_001366644 NM_001366645 NM_001366646 NM_001159485 NM_001159486 NM_178076 RefSeq (protein) NP_001106203 NP_001307744 NP_001307745 NP_001307746 NP_079255 NP_001353573 NP_001353574 NP_001353575 n/a Location (UCSC) Chr 13: 112.89 – 113.1 Mb Chr 8: 12.87 – 13.02 Mb PubMed search [3] [4]
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