Melanin-concentrating hormone receptor 2

Melanin-concentrating hormone receptor 2 (MCH₂) also known as G-protein coupled receptor 145 (GPR145) is a protein that in humans is encoded by the MCHR2 gene.^[3][4][5]

AliasesMCHR2, GPR145, GPRv17, MCH-2R, MCH-R2, MCH2, MCH2R, MCHR-2, SLT, melanin concentrating hormone receptor 2

External IDsOMIM: 606111; HomoloGene: 50004; GeneCards: MCHR2; OMA:MCHR2 - orthologs

Chr.Chromosome 6 (human)^[1]

End99,994,247 bp^[1]

Quick facts MCHR2, Identifiers ...

MCHR2
Identifiers
Aliases	MCHR2, GPR145, GPRv17, MCH-2R, MCH-R2, MCH2, MCH2R, MCHR-2, SLT, melanin concentrating hormone receptor 2
External IDs	OMIM: 606111; HomoloGene: 50004; GeneCards: MCHR2; OMA:MCHR2 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q16.2 Start 99,918,519 bp[1] End 99,994,247 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in prefrontal cortex dorsolateral prefrontal cortex Brodmann area 9 Brodmann area 46 testicle right frontal lobe superior frontal gyrus anterior cingulate cortex primary visual cortex postcentral gyrus n/a More reference expression data BioGPS n/a
Gene ontology Molecular function G protein-coupled peptide receptor activity G protein-coupled receptor activity signal transducer activity Cellular component integral component of membrane plasma membrane integral component of plasma membrane membrane Biological process phospholipase C-activating G protein-coupled receptor signaling pathway neuropeptide signaling pathway signal transduction G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 84539 n/a Ensembl ENSG00000152034 n/a UniProt Q969V1 n/a RefSeq (mRNA) NM_032503 NM_001040179 n/a RefSeq (protein) NP_001035269 NP_115892 n/a Location (UCSC) Chr 6: 99.92 – 99.99 Mb n/a PubMed search [2] n/a
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MCH₂ is also found in dogs, ferrets, and some other primates and carnivores, but is not found in mice or rats. This has delayed research into the receptor as a therapeutic target, due to most early pharmaceutical research usually being conducted in small mammals such as mice, rats or rabbits which lack the MCH₂ gene and its receptor product.