MCM5

Protein-coding gene in humans From Wikipedia, the free encyclopedia

DNA replication licensing factor MCM5 is a protein that in humans is encoded by the MCM5 gene.[5][6][7]

AliasesMCM5, CDC46, P1-CDC46, minichromosome maintenance complex component 5, MGORS8
End35,425,431 bp[1]
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MCM5
Identifiers
AliasesMCM5, CDC46, P1-CDC46, minichromosome maintenance complex component 5, MGORS8
External IDsOMIM: 602696; MGI: 103197; HomoloGene: 4904; GeneCards: MCM5; OMA:MCM5 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006739

NM_008566
NM_001302540

RefSeq (protein)

NP_006730

NP_001289469
NP_032592

Location (UCSC)Chr 22: 35.4 – 35.43 MbChr 8: 75.84 – 75.86 Mb
PubMed search[3][4]
Wikidata
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Function

The protein encoded by this gene is structurally very similar to the CDC46 protein from S. cerevisiae, a protein involved in the initiation of DNA replication. The encoded protein is a member of the MCM family of chromatin-binding proteins and can interact with at least two other members of this family. The encoded protein is upregulated in the transition from the G0 to G1/S phase of the cell cycle and may actively participate in cell cycle regulation.[7]

See also

Interactions

References

Further reading

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