MDFI
Protein-coding gene in the species Homo sapiens
From Wikipedia, the free encyclopedia
MyoD family inhibitor is a protein that in humans is encoded by the MDFI gene.[5][6][7]
External IDsOMIM: 604971; MGI: 107687; HomoloGene: 21150; GeneCards: MDFI; OMA:MDFI - orthologs
Function
This protein is a transcription factor that negatively regulates other myogenic family proteins. Studies of the mouse homolog, I-mf, show that it interferes with myogenic factor function by masking nuclear localization signals and preventing DNA binding. Knockout mouse studies show defects in the formation of vertebrae and ribs that also involve cartilage formation in these structures.[7]