MDFI

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

MyoD family inhibitor is a protein that in humans is encoded by the MDFI gene.[5][6][7]

AliasesMDFI, MyoD family inhibitor, I-MF, I-mfa
End41,654,244 bp[1]
Quick facts Identifiers, Aliases ...
MDFI
Identifiers
AliasesMDFI, MyoD family inhibitor, I-MF, I-mfa
External IDsOMIM: 604971; MGI: 107687; HomoloGene: 21150; GeneCards: MDFI; OMA:MDFI - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001300804
NM_001300805
NM_001300806
NM_005586

NM_001109973
NM_001276390
NM_001276391
NM_010783

RefSeq (protein)

NP_001287733
NP_001287734
NP_001287735
NP_005577

NP_001103443
NP_001263319
NP_001263320
NP_034913

Location (UCSC)Chr 6: 41.64 – 41.65 MbChr 17: 48.13 – 48.15 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse
Close

Function

This protein is a transcription factor that negatively regulates other myogenic family proteins. Studies of the mouse homolog, I-mf, show that it interferes with myogenic factor function by masking nuclear localization signals and preventing DNA binding. Knockout mouse studies show defects in the formation of vertebrae and ribs that also involve cartilage formation in these structures.[7]

Interactions

MDFI has been shown to interact with:

References

Further reading

Related Articles

Wikiwand AI