MED22

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

Mediator of RNA polymerase II transcription subunit 22 is an enzyme that in humans is encoded by the MED22 gene.[5][6][7]

AliasesMED22, MED24, SURF5, surf-5, mediator complex subunit 22, SRB6
End133,348,131 bp[1]
Quick facts Identifiers, Aliases ...
MED22
Identifiers
AliasesMED22, MED24, SURF5, surf-5, mediator complex subunit 22, SRB6
External IDsOMIM: 185641; MGI: 98446; HomoloGene: 4913; GeneCards: MED22; OMA:MED22 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_181491
NM_006752
NM_133640

NM_001033908
NM_011513
NM_001378786
NM_001378787
NM_001378788

RefSeq (protein)

NP_598395
NP_852468

NP_001029080
NP_035643
NP_001365715
NP_001365716
NP_001365717

Location (UCSC)Chr 9: 133.34 – 133.35 MbChr 2: 26.8 – 26.8 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse
Close

Function

This gene is located in the surfeit gene cluster, a group of very tightly linked housekeeping genes that do not share sequence similarity. The gene is oriented in a head-to-head fashion with RPL7A (SURF3) and the two genes share a bidirectional promoter. The encoded proteins are localized to the cytoplasm. Two alternative transcript variants encoding different isoforms have been identified for this gene.[7]

Interactions

MED22 has been shown to interact with MED30.[8]

References

Further reading

Related Articles

Wikiwand AI