MED6

Available protein structures:
PDB	IPR007018 PF04934 (ECOD; PDBsum)
AlphaFold	IPR007018; PF04934;

Med6
Med6
Identifiers
Symbol	Med6
Pfam	PF04934
InterPro	IPR007018
PDB
Available protein structures:
PDB	IPR007018 PF04934 (ECOD; PDBsum)
AlphaFold	IPR007018; PF04934;

MED6
Identifiers
Aliases	MED6, ARC33, NY-REN-28, mediator complex subunit 6
External IDs	OMIM: 602984; MGI: 1917042; HomoloGene: 3990; GeneCards: MED6; OMA:MED6 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	70,600,690 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	81,641,782 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; testicle; ; islet of Langerhans; ; monocyte; ; skin of leg; ; skin of abdomen; ; ganglionic eminence; ; muscle of thigh; ; gastrocnemius muscle; ; rectum;
	Top expressed in
	zygote; ; genital tubercle; ; tail of embryo; ; yolk sac; ; morula; ; neural layer of retina; ; interventricular septum; ; maxillary prominence; ; mandibular prominence; ; epiblast;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transcription coactivator activity; transcription coregulator activity; transcription factor binding; protein binding;
Cellular component	mediator complex; core mediator complex; membrane; nucleus; nucleoplasm;
Biological process	regulation of transcription by RNA polymerase II; RNA polymerase II preinitiation complex assembly; transcription initiation from RNA polymerase II promoter; regulation of transcription, DNA-templated; positive regulation of transcription by RNA polymerase II; transcription, DNA-templated;
	Sources:Amigo / QuickGO
Orthologs
	10001
	69792
	ENSG00000133997
	ENSMUSG00000002679
	O75586
	Q921D4
	NM_005466; NM_001284209; NM_001284210; NM_001284211
	NM_027213; NM_001347384; NM_001347385; NM_001347386
	NP_001271138; NP_001271139; NP_001271140; NP_005457
	NP_001334313; NP_001334314; NP_001334315
	Wikidata
View/Edit Human	View/Edit Mouse

Mediator of RNA polymerase II transcription subunit 6 is one of the subunits of the Mediator complex. It is an enzyme that in humans is encoded by the MED6 gene.^[5]^[6]^[7]