MED8

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

Mediator of RNA polymerase II transcription subunit 8 is an enzyme that in humans is encoded by the MED8 gene.[5][6][7]

AliasesMED8, ARC32, mediator complex subunit 8
End43,389,808 bp[1]
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MED8
Identifiers
AliasesMED8, ARC32, mediator complex subunit 8
External IDsOMIM: 607956; MGI: 1915269; HomoloGene: 10560; GeneCards: MED8; OMA:MED8 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_201542
NM_001001653
NM_052877

NM_001290688
NM_020000
NM_173719

RefSeq (protein)

NP_001001653
NP_443109
NP_963836

NP_001277617
NP_064384
NP_776067

Location (UCSC)Chr 1: 43.38 – 43.39 MbChr 4: 118.27 – 118.27 Mb
PubMed search[3][4]
Wikidata
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Function

This gene encodes a protein that is one of more than 20 subunits of the mediator complex, first identified in S. cerevisiae, that is required for activation of transcription. The product of this gene also interacts with elongins B and C, and CUL2 and RBX1, to reconstitute a ubiquitin ligase. Five alternative transcripts encoding four isoforms have been described.[7]

Interactions

MED8 has been shown to interact with MED26.[8]

References

Further reading

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