MEP1B

Meprin A subunit beta is a protein that in humans is encoded by the MEP1B gene.^[5][6]

PDBOrtholog search: PDBe RCSB

AliasesMEP1B, meprin A subunit beta

External IDsOMIM: 600389; MGI: 96964; HomoloGene: 48382; GeneCards: MEP1B; OMA:MEP1B - orthologs

Chr.Chromosome 18 (human)^[1]

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MEP1B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4GWM, 4GWN
Identifiers
Aliases	MEP1B, meprin A subunit beta
External IDs	OMIM: 600389; MGI: 96964; HomoloGene: 48382; GeneCards: MEP1B; OMA:MEP1B - orthologs
Gene location (Human) Chr. Chromosome 18 (human)[1] Band 18q12.1 Start 32,185,069 bp[1] End 32,220,404 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18 A2|18 11.81 cM Start 21,194,980 bp[2] End 21,233,256 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in jejunal mucosa mucosa of ileum duodenum mucosa of transverse colon gonad testicle rectum gastric mucosa islet of Langerhans smooth muscle tissue Top expressed in ileum jejunum right kidney duodenum intestinal epithelium human kidney large intestine colon proximal tubule Paneth cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peptidase activity metalloendopeptidase activity protein binding metallopeptidase activity hydrolase activity metal ion binding identical protein binding zinc ion binding Cellular component integral component of membrane extracellular region membrane plasma membrane integral component of plasma membrane meprin A complex Biological process inflammatory response toxin transport proteolysis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4225 17288 Ensembl ENSG00000141434 ENSMUSG00000024313 UniProt Q16820 Q61847 RefSeq (mRNA) NM_001308171 NM_005925 NM_008586 RefSeq (protein) NP_001295100 NP_005916 NP_032612 Location (UCSC) Chr 18: 32.19 – 32.22 Mb Chr 18: 21.19 – 21.23 Mb PubMed search [3] [4]
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Meprins are multidomain zinc metalloproteases that are highly expressed in mammalian kidney and intestinal brush border membranes and in leukocytes and certain cancer cells. Mature meprins are oligomers of evolutionarily related, separately encoded alpha and/or beta subunits. Homooligomers of meprin-alpha (MEP1A; MIM 600388) are secreted; oligomers containing meprin-beta are associated with the plasma membrane. Substrates include bioactive peptides and extracellular matrix proteins. See MIM 600388 for further information on meprins.[supplied by OMIM]^[6]