Mesoderm-specific transcript homolog protein

Mesoderm-specific transcript homolog protein is a protein that in humans is encoded by the MEST gene.^[5][6]

AliasesMEST, PEG1, mesoderm specific transcript

External IDsOMIM: 601029; MGI: 96968; HomoloGene: 1800; GeneCards: MEST; OMA:MEST - orthologs

Chr.Chromosome 7 (human)^[1]

End130,506,465 bp^[1]

Quick facts MEST, Identifiers ...

MEST
Identifiers
Aliases	MEST, PEG1, mesoderm specific transcript
External IDs	OMIM: 601029; MGI: 96968; HomoloGene: 1800; GeneCards: MEST; OMA:MEST - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q32.2 Start 130,486,171 bp[1] End 130,506,465 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 A3.3|6 12.53 cM Start 30,723,547 bp[2] End 30,748,465 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cartilage tissue placenta secondary oocyte pericardium parietal pleura ventricular zone abdominal fat embryo lactiferous duct right adrenal gland Top expressed in mandibular prominence dermis left lung lobe human fetus atrium abdominal wall genital tubercle maxillary prominence efferent ductule Gonadal ridge More reference expression data BioGPS More reference expression data
Gene ontology Molecular function catalytic activity hydrolase activity Cellular component integral component of membrane extracellular exosome endoplasmic reticulum membrane endoplasmic reticulum membrane Biological process mesoderm development regulation of lipid storage Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4232 17294 Ensembl ENSG00000106484 ENSMUSG00000051855 UniProt Q5EB52 Q07646 RefSeq (mRNA) NM_001253900 NM_001253901 NM_001253902 NM_002402 NM_177524 NM_177525 NM_001252292 NM_001252293 NM_008590 RefSeq (protein) NP_001240829 NP_001240830 NP_001240831 NP_002393 NP_803490 NP_803491 NP_001239221 NP_001239222 NP_032616 Location (UCSC) Chr 7: 130.49 – 130.51 Mb Chr 6: 30.72 – 30.75 Mb PubMed search [3] [4]
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This gene encodes a member of the Alpha/beta hydrolase superfamily and has isoform-specific imprinting. The loss of imprinting of this gene has been linked to certain types of cancer and may be due to promoter switching. The encoded protein may play a role in development. Three transcript variants encoding two distinct isoforms have been identified for this gene. A pseudogene for this locus is located on chromosome 6.^[6]