MGAT1

Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase is an enzyme that in humans is encoded by the MGAT1 gene.^[5][6]

AliasesMGAT1, GLCNAC-TI, GLCT1, GLYT1, GNT-1, GNT-I, MGAT, GnTI, mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase

External IDsOMIM: 160995; MGI: 96973; HomoloGene: 1804; GeneCards: MGAT1; OMA:MGAT1 - orthologs

Chr.Chromosome 5 (human)^[1]

End180,815,652 bp^[1]

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MGAT1
Identifiers
Aliases	MGAT1, GLCNAC-TI, GLCT1, GLYT1, GNT-1, GNT-I, MGAT, GnTI, mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
External IDs	OMIM: 160995; MGI: 96973; HomoloGene: 1804; GeneCards: MGAT1; OMA:MGAT1 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q35.3 Start 180,784,782 bp[1] End 180,815,652 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 B1.2|11 29.27 cM Start 49,135,018 bp[2] End 49,153,857 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte granulocyte right lung gastric mucosa upper lobe of left lung apex of heart right lobe of thyroid gland left uterine tube spleen left lobe of thyroid gland Top expressed in neural layer of retina granulocyte thymus yolk sac right kidney choroid plexus of fourth ventricle proximal tubule tibiofemoral joint molar lip More reference expression data BioGPS More reference expression data
Gene ontology Molecular function glycosyltransferase activity transferase activity acetylglucosaminyltransferase activity metal ion binding alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity manganese ion binding Cellular component integral component of membrane extracellular vesicle Golgi membrane Golgi apparatus extracellular exosome membrane Biological process protein glycosylation in utero embryonic development UDP-N-acetylglucosamine catabolic process carbohydrate metabolic process protein N-linked glycosylation protein N-linked glycosylation via asparagine Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4245 17308 Ensembl ENSG00000131446 ENSMUSG00000020346 UniProt P26572 P27808 RefSeq (mRNA) NM_001114617 NM_001114618 NM_001114619 NM_001114620 NM_002406 NM_001110148 NM_001110149 NM_001110150 NM_010794 RefSeq (protein) NP_001108089 NP_001108090 NP_001108091 NP_001108092 NP_002397 NP_001351306 NP_001351308 NP_001351309 NP_001351310 NP_001351311 NP_001351312 NP_001351313 NP_001351314 NP_001351315 NP_001351316 NP_001351317 NP_001351318 NP_001351319 NP_001351320 NP_001351321 NP_001351322 NP_001351323 NP_001351324 NP_001103618 NP_001103619 NP_001103620 NP_034924 Location (UCSC) Chr 5: 180.78 – 180.82 Mb Chr 11: 49.14 – 49.15 Mb PubMed search [3] [4]
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There are over 100 different glycosyltransferases involved in the synthesis of protein-bound and lipid-bound oligosaccharides. UDP-N-acetylglucosamine:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I is a medial-Golgi enzyme essential for the synthesis of hybrid and complex N-glycans. The protein, encoded by a single exon, shows typical features of a type II transmembrane protein. The protein is believed to be essential for normal embryogenesis.^[6]