MGAT2

Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase is an enzyme that in humans is encoded by the MGAT2 gene.^[5][6]

AliasesMGAT2, CDG2A, CDGS2, GLCNACTII, GNT-II, GNT2, mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase, alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

External IDsOMIM: 602616; MGI: 2384966; HomoloGene: 1806; GeneCards: MGAT2; OMA:MGAT2 - orthologs

Chr.Chromosome 14 (human)^[1]

End49,623,481 bp^[1]

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MGAT2
Identifiers
Aliases	MGAT2, CDG2A, CDGS2, GLCNACTII, GNT-II, GNT2, mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase, alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
External IDs	OMIM: 602616; MGI: 2384966; HomoloGene: 1806; GeneCards: MGAT2; OMA:MGAT2 - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q21.3 Start 49,620,799 bp[1] End 49,623,481 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12|12 C2 Start 69,230,931 bp[2] End 69,233,544 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in jejunal mucosa mucosa of sigmoid colon decidua periodontal fiber corpus epididymis caput epididymis bronchial epithelial cell tail of epididymis seminal vesicula skin of hip Top expressed in parotid gland seminal vesicula epithelium of stomach decidua calvaria right kidney gastrula medullary collecting duct transitional epithelium of urinary bladder pyloric antrum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity carbohydrate binding glycosyltransferase activity manganese ion binding protein homodimerization activity metal ion binding Cellular component integral component of membrane Golgi membrane Golgi stack Golgi apparatus membrane Biological process protein glycosylation oligosaccharide biosynthetic process protein N-linked glycosylation oligosaccharide metabolic process protein N-linked glycosylation via asparagine Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4247 217664 Ensembl ENSG00000168282 ENSMUSG00000043998 UniProt Q10469 Q921V5 RefSeq (mRNA) NM_002408 NM_001015883 NM_146035 RefSeq (protein) NP_002399 NP_666147 Location (UCSC) Chr 14: 49.62 – 49.62 Mb Chr 12: 69.23 – 69.23 Mb PubMed search [3] [4]
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The product of this gene is a Golgi enzyme catalyzing an essential step in the conversion of oligomannose to complex N-glycans. The enzyme has the typical glycosyltransferase domains: a short N-terminal cytoplasmic domain, a hydrophobic non-cleavable signal-anchor domain, and a C-terminal catalytic domain. Mutations in this gene may lead to carbohydrate-deficient glycoprotein syndrome, type II. The coding region of this gene is intronless. Transcript variants with a spliced 5' UTR may exist, but their biological validity has not been determined.^[6]