MGAT3

Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase is an enzyme that in humans is encoded by the MGAT3 gene.^[5][6]

AliasesMGAT3, GNT-III, GNT3, mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase

External IDsOMIM: 604621; MGI: 104532; HomoloGene: 31088; GeneCards: MGAT3; OMA:MGAT3 - orthologs

Chr.Chromosome 22 (human)^[1]

End39,492,194 bp^[1]

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MGAT3
Identifiers
Aliases	MGAT3, GNT-III, GNT3, mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase
External IDs	OMIM: 604621; MGI: 104532; HomoloGene: 31088; GeneCards: MGAT3; OMA:MGAT3 - orthologs
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q13.1 Start 39,457,012 bp[1] End 39,492,194 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15 E1|15 37.85 cM Start 80,057,922 bp[2] End 80,099,720 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum right frontal lobe prefrontal cortex Brodmann area 9 olfactory bulb nucleus accumbens cingulate gyrus dorsal motor nucleus of vagus nerve amygdala anterior cingulate cortex Top expressed in dentate gyrus of hippocampal formation granule cell superior frontal gyrus right kidney primary visual cortex cerebellar cortex proximal tubule supraoptic nucleus lumbar subsegment of spinal cord facial motor nucleus ventricular zone More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity glycosyltransferase activity beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity Cellular component integral component of membrane Golgi membrane Golgi apparatus membrane Biological process protein glycosylation protein N-linked glycosylation N-acetylglucosamine metabolic process protein localization regulation of cell migration cellular response to oxidative stress amyloid-beta metabolic process cognition positive regulation of protein localization to early endosome negative regulation of lysosomal protein catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4248 17309 Ensembl ENSG00000128268 ENSMUSG00000042428 UniProt Q09327 Q10470 Q5RKT9 RefSeq (mRNA) NM_001098270 NM_002409 NM_010795 RefSeq (protein) NP_001091740 NP_002400 NP_034925 Location (UCSC) Chr 22: 39.46 – 39.49 Mb Chr 15: 80.06 – 80.1 Mb PubMed search [3] [4]
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There are believed to be over 100 different glycosyltransferases involved in the synthesis of protein-bound and lipid-bound oligosaccharides. The enzyme encoded by this gene transfers a GlcNAc residue to the beta-linked mannose of the trimannosyl core of N-linked oligosaccharides and produces a bisecting GlcNAc. Multiple alternatively spliced variants, encoding the same protein, have been identified.^[6]