MGAT4B

MGAT4B
Identifiers
Aliases	MGAT4B, GNT-IV, GNT-IVB, mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B, alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B
External IDs	OMIM: 604561; MGI: 2143974; HomoloGene: 8611; GeneCards: MGAT4B; OMA:MGAT4B - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	179,806,952 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	50,125,930 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; duodenum; ; stromal cell of endometrium; ; rectum; ; right lobe of liver; ; apex of heart; ; right hemisphere of cerebellum; ; left adrenal cortex; ; islet of Langerhans; ; right adrenal gland;
	Top expressed in
	crypt of lieberkuhn of small intestine; ; ankle; ; stroma of bone marrow; ; olfactory epithelium; ; right kidney; ; gastrula; ; yolk sac; ; endothelial cell of lymphatic vessel; ; left colon; ; pyloric antrum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity; acetylglucosaminyltransferase activity; metal ion binding; glycosyltransferase activity; hexosyltransferase activity;
Cellular component	integral component of membrane; Golgi membrane; Golgi apparatus; membrane; endoplasmic reticulum; endoplasmic reticulum-Golgi intermediate compartment; Golgi stack;
Biological process	protein glycosylation; N-glycan processing; protein N-linked glycosylation; carbohydrate metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	11282
	103534
	ENSG00000284501; ENSG00000161013
	ENSMUSG00000036620
	Q9UQ53
	Q812F8
	NM_054013; NM_014275
	NM_145926
	NP_055090; NP_463459
	NP_666038
	Wikidata
View/Edit Human	View/Edit Mouse

Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B is an enzyme that in humans is encoded by the MGAT4B gene.^[5]^[6]

AliasesMGAT4B, GNT-IV, GNT-IVB, mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B, alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B

External IDsOMIM: 604561; MGI: 2143974; HomoloGene: 8611; GeneCards: MGAT4B; OMA:MGAT4B - orthologs

Chr.Chromosome 5 (human)^[1]

End179,806,952 bp^[1]

Quick facts Identifiers, Aliases ...

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This gene encodes a key glycosyltransferase that regulates the formation of tri- and multiantennary branching structures in the Golgi apparatus. The encoded protein, in addition to the related isoenzyme A, catalyzes the transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc in a beta-1,4 linkage to the Man-alpha-1,3-Man-beta-1,4-GlcNAc arm of R-Man-alpha-1,6(GlcNAc-beta-1,2-Man-alpha-1,3)Man-beta-1,4-GlcNAc-beta-1,4-GlcNAc-beta-1-Asn. Therefore, the protein is essential for the production of tri- and tetra-antennary sugar chains. The encoded protein may play a role in regulating the availability of serum glycoproteins, oncogenesis, and differentiation.^[6] Its affinities for donors of acceptors are lower than that of MGAT4A so it is suggested that it is not the main contributor in N-glycan biosynthesis.^[7]

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[6]

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MGAT4B

References

Further reading

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