MGAT5

Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A is an enzyme that in humans is encoded by the MGAT5 gene.^[5][6]

AliasesMGAT5, GNT-V, GNT-VA, mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase, MGAT5A, glcNAc-T V

External IDsOMIM: 601774; MGI: 894701; HomoloGene: 1808; GeneCards: MGAT5; OMA:MGAT5 - orthologs

Chr.Chromosome 2 (human)^[1]

End134,454,621 bp^[1]

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MGAT5
Identifiers
Aliases	MGAT5, GNT-V, GNT-VA, mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase, MGAT5A, glcNAc-T V
External IDs	OMIM: 601774; MGI: 894701; HomoloGene: 1808; GeneCards: MGAT5; OMA:MGAT5 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q21.2-q21.3 Start 134,119,983 bp[1] End 134,454,621 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 E3 Start 127,132,752 bp[2] End 127,416,073 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in glomerulus metanephric glomerulus middle temporal gyrus Brodmann area 23 tibia pons cardiac muscle tissue of right atrium pars reticulata bronchial epithelial cell myocardium of left ventricle Top expressed in Paneth cell renal corpuscle medial geniculate nucleus molar pontine nuclei lateral geniculate nucleus pituitary gland median eminence habenula substantia nigra More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity acetylglucosaminyltransferase activity glycosyltransferase activity alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity protein phosphatase inhibitor activity manganese ion binding Cellular component integral component of membrane Golgi membrane extracellular exosome membrane Golgi apparatus extracellular region Biological process protein glycosylation protein N-linked glycosylation protein N-linked glycosylation via asparagine positive regulation of cell migration negative regulation of protein tyrosine phosphatase activity positive regulation of receptor signaling pathway via STAT Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4249 107895 Ensembl ENSG00000152127 ENSMUSG00000036155 UniProt Q09328 Q8R4G6 RefSeq (mRNA) NM_002410 NM_001371457 NM_145128 RefSeq (protein) NP_002401 NP_001358386 NP_660110 Location (UCSC) Chr 2: 134.12 – 134.45 Mb Chr 1: 127.13 – 127.42 Mb PubMed search [3] [4]
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This gene encodes mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, a glycosyltransferase involved in the synthesis of protein-bound and lipid-bound oligosaccharides. Alterations of the oligosaccharides on cell surface glycoproteins cause significant changes in the adhesive or migratory behavior of a cell. Increase in the encoded protein's activity may correlate with the progression of invasive malignancies.^[6]