MGST3

Microsomal glutathione S-transferase 3 is an enzyme that in humans is encoded by the MGST3 gene.^[5][6]

AliasesMGST3, GST-III, microsomal glutathione S-transferase 3

External IDsOMIM: 604564; MGI: 1913697; HomoloGene: 3327; GeneCards: MGST3; OMA:MGST3 - orthologs

Chr.Chromosome 1 (human)^[1]

End165,661,796 bp^[1]

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MGST3
Identifiers
Aliases	MGST3, GST-III, microsomal glutathione S-transferase 3
External IDs	OMIM: 604564; MGI: 1913697; HomoloGene: 3327; GeneCards: MGST3; OMA:MGST3 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q24.1 Start 165,631,213 bp[1] End 165,661,796 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 H2.3 Start 167,199,535 bp[2] End 167,221,410 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in corpus epididymis jejunal mucosa Skeletal muscle tissue of rectus abdominis pons right ventricle thoracic diaphragm apex of heart duodenum Skeletal muscle tissue of biceps brachii mucosa of sigmoid colon Top expressed in fetal liver hematopoietic progenitor cell mucous cell of stomach epithelium of stomach pyloric antrum olfactory epithelium digastric muscle temporal muscle right ventricle interventricular septum duodenum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity protein binding glutathione transferase activity leukotriene-C4 synthase activity glutathione peroxidase activity oxidoreductase activity lyase activity Cellular component integral component of membrane organelle membrane extracellular exosome endoplasmic reticulum membrane nuclear envelope endoplasmic reticulum membrane intracellular membrane-bounded organelle Biological process xenobiotic metabolic process glutathione derivative biosynthetic process response to organonitrogen compound cellular oxidant detoxification lipid metabolism leukotriene biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4259 66447 Ensembl ENSG00000143198 ENSMUSG00000026688 UniProt O14880 Q9CPU4 RefSeq (mRNA) NM_004528 NM_025569 NM_029392 RefSeq (protein) NP_004519 NP_079845 Location (UCSC) Chr 1: 165.63 – 165.66 Mb Chr 1: 167.2 – 167.22 Mb PubMed search [3] [4]
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The MAPEG (Membrane-Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, several of which are involved the production of leukotrienes and prostaglandin E, important mediators of inflammation. This gene encodes an enzyme that catalyzes the conjugation of leukotriene A4 and reduced glutathione to produce leukotriene C4. This enzyme also demonstrates glutathione-dependent peroxidase activity towards lipid hydroperoxides.^[6]