MKI67IP

MKI67 FHA domain-interacting nucleolar phosphoprotein is a protein that in humans is encoded by the MKI67IP gene.^[5][6]

PDBOrtholog search: PDBe RCSB

AliasesNIFK, MKI67IP, Nopp34, nucleolar protein interacting with the FHA domain of MKI67

External IDsOMIM: 611970; MGI: 1915199; HomoloGene: 49862; GeneCards: NIFK; OMA:NIFK - orthologs

Chr.Chromosome 2 (human)^[1]

Quick facts NIFK, Available structures ...

NIFK
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2AFF
Identifiers
Aliases	NIFK, MKI67IP, Nopp34, nucleolar protein interacting with the FHA domain of MKI67
External IDs	OMIM: 611970; MGI: 1915199; HomoloGene: 49862; GeneCards: NIFK; OMA:NIFK - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q14.3 Start 121,726,945 bp[1] End 121,736,911 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 E2.3 Start 118,249,569 bp[2] End 118,261,552 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon ventricular zone ganglionic eminence cartilage tissue tibialis anterior muscle mucosa of sigmoid colon body of pancreas lymph node endometrium appendix Top expressed in primitive streak genital tubercle epiblast embryo embryo tail of embryo morula morula yolk sac ventricular zone More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding RNA binding nucleic acid binding Cellular component cytoplasm condensed nuclear chromosome chromosome nucleolus nucleus nucleoplasm Biological process negative regulation of phosphatase activity rRNA transcription rRNA metabolic process protein-containing complex assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 84365 67949 Ensembl ENSG00000155438 ENSMUSG00000026377 UniProt Q9BYG3 Q91VE6 RefSeq (mRNA) NM_032390 NM_026472 RefSeq (protein) NP_115766 NP_080748 Location (UCSC) Chr 2: 121.73 – 121.74 Mb Chr 1: 118.25 – 118.26 Mb PubMed search [3] [4]
Wikidata
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SymbolhNIFK_binding

PfamPF12196

InterProIPR021043

PDBIPR021043 PF12196 (ECOD; PDBsum)  

Quick facts FHA Ki67 binding domain of hNIFK, Identifiers ...

FHA Ki67 binding domain of hNIFK
the solution structure of the ki67fha/hnifk(226-269)3p complex
Identifiers
Symbol	hNIFK_binding
Pfam	PF12196
InterPro	IPR021043
Available protein structures: PDB   IPR021043 PF12196 (ECOD; PDBsum)   AlphaFold IPR021043 PF12196

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MKI67 FHA domain-interacting nucleolar phosphoprotein contains an RNA recognition motif (RRM) near to the N-terminus and a FHA Ki67 binding domain near to the C-terminus. There are two conserved sequence motifs within the FHA Ki67 binding domain: TPVCTP and LERRKS, this domain binds to the forkhead-associated domain of human Ki67. High-affinity binding requires sequential phosphorylation by two kinases, CDK1 and GSK3, yielding pThr238, pThr234 and pSer230. This interaction is involved in cell cycle regulation.^[7]