MAP2K3

Dual specificity mitogen-activated protein kinase kinase 3 is an enzyme that in humans is encoded by the MAP2K3 gene.^[5]

PDBOrtholog search: PDBe RCSB

AliasesMAP2K3, MAPKK3, MEK3, MKK3, PRKMK3, SAPKK-2, SAPKK2, mitogen-activated protein kinase kinase 3

External IDsOMIM: 602315; MGI: 1346868; HomoloGene: 56430; GeneCards: MAP2K3; OMA:MAP2K3 - orthologs

Chr.Chromosome 17 (human)^[1]

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MAP2K3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1LEZ
Identifiers
Aliases	MAP2K3, MAPKK3, MEK3, MKK3, PRKMK3, SAPKK-2, SAPKK2, mitogen-activated protein kinase kinase 3
External IDs	OMIM: 602315; MGI: 1346868; HomoloGene: 56430; GeneCards: MAP2K3; OMA:MAP2K3 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17p11.2 Start 21,284,672 bp[1] End 21,315,232 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 B2 Start 60,822,859 bp[2] End 60,843,637 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell vena cava blood body of tongue saphenous vein mucosa of pharynx pylorus superior surface of tongue cardia monocyte Top expressed in temporal muscle sternocleidomastoid muscle ankle digastric muscle triceps brachii muscle muscle of thigh fetal liver hematopoietic progenitor cell lip esophagus vastus lateralis muscle More reference expression data BioGPS n/a
Gene ontology Molecular function ATP binding protein tyrosine kinase activity protein kinase activity protein binding kinase activity nucleotide binding transferase activity MAP kinase kinase activity protein kinase binding protein serine/threonine kinase activity Cellular component nucleoplasm cytosol membrane cytoplasm Biological process MAPK cascade protein phosphorylation positive regulation of transcription, DNA-templated peptidyl-tyrosine phosphorylation phosphorylation signal transduction positive regulation of protein kinase activity inflammatory response cardiac muscle contraction regulation of mitotic cell cycle stress-activated protein kinase signaling cascade activation of protein kinase activity regulation of apoptotic process cellular response to vascular endothelial growth factor stimulus p38MAPK cascade positive regulation of blood vessel endothelial cell migration Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5606 26397 Ensembl ENSG00000034152 ENSMUSG00000018932 UniProt P46734 O09110 RefSeq (mRNA) NM_002756 NM_145109 NM_145110 NM_001316332 NM_008928 RefSeq (protein) NP_001303261 NP_002747 NP_659731 NP_032954 Location (UCSC) Chr 17: 21.28 – 21.32 Mb Chr 11: 60.82 – 60.84 Mb PubMed search [3] [4]
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The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersinia pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene.^[6]