MKL2

MKL/myocardin-like protein 2 is a protein that in humans is encoded by the MKL2 gene.^[5][6]

AliasesMRTFB, MRTF-B, NPD001, MKL1/myocardin like 2, myocardin related transcription factor B, MKL2

External IDsOMIM: 609463; MGI: 3050795; HomoloGene: 40917; GeneCards: MRTFB; OMA:MRTFB - orthologs

Chr.Chromosome 16 (human)^[1]

End14,266,773 bp^[1]

Quick facts MRTFB, Identifiers ...

MRTFB
Identifiers
Aliases	MRTFB, MRTF-B, NPD001, MKL1/myocardin like 2, myocardin related transcription factor B, MKL2
External IDs	OMIM: 609463; MGI: 3050795; HomoloGene: 40917; GeneCards: MRTFB; OMA:MRTFB - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p13.12 Start 14,071,321 bp[1] End 14,266,773 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16|16 A1 Start 13,074,345 bp[2] End 13,235,393 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Brodmann area 23 endothelial cell middle temporal gyrus Region I of hippocampus proper entorhinal cortex superior frontal gyrus orbitofrontal cortex postcentral gyrus visceral pleura Brodmann area 46 Top expressed in olfactory tubercle piriform cortex nucleus accumbens primary motor cortex anterior amygdaloid area cingulate gyrus lateral septal nucleus ventromedial nucleus Region I of hippocampus proper subiculum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transcription coactivator activity protein binding cadherin binding Cellular component nucleus Biological process multicellular organism development muscle organ development regulation of transcription, DNA-templated smooth muscle cell differentiation positive regulation of striated muscle tissue development positive regulation of transcription by RNA polymerase II cell differentiation transcription, DNA-templated transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57496 239719 Ensembl ENSG00000186260 ENSMUSG00000009569 UniProt Q9ULH7 P59759 RefSeq (mRNA) NM_001308142 NM_014048 NM_001122667 NM_153588 NM_181860 RefSeq (protein) NP_001295071 NP_054767 NP_001352340 NP_001352341 NP_001352342 NP_001352343 NP_001352344 NP_001352345 NP_001352346 NP_001352347 NP_001352348 NP_001352349 NP_001352350 NP_001116139 NP_705816 NP_862908 Location (UCSC) Chr 16: 14.07 – 14.27 Mb Chr 16: 13.07 – 13.24 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Close

Members of the myocardin family bind to the transcription factor serum response factor (SRF) and act as coactivators controlling genes of relevance for myogenic differentiation, motile function ^[7] and addiction. ^[8]