MKNK2

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

MAP kinase-interacting serine/threonine-protein kinase 2 is an enzyme that in humans is encoded by the MKNK2 gene.[5][6]

PDBOrtholog search: PDBe RCSB
AliasesMKNK2, GPRK7, MNK2, MAP kinase interacting serine/threonine kinase 2, MAPK interacting serine/threonine kinase 2
Quick facts Available structures, PDB ...
MKNK2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMKNK2, GPRK7, MNK2, MAP kinase interacting serine/threonine kinase 2, MAPK interacting serine/threonine kinase 2
External IDsOMIM: 605069; MGI: 894279; HomoloGene: 49674; GeneCards: MKNK2; OMA:MKNK2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_199054
NM_017572

NM_021462

RefSeq (protein)

NP_060042
NP_951009

NP_067437

Location (UCSC)Chr 19: 2.04 – 2.05 MbChr 10: 80.5 – 80.51 Mb
PubMed search[3][4]
Wikidata
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Interactions

MNK2 has been shown to interact with MAPK1[7][8] and Eukaryotic translation initiation factor 4 gamma.[7]

MNK2 has been identified as a therapeutic target for diabetes. Specifically, blocking MNK2 interaction with eIF4G has been shown to boost protein synthesis and promote beta cell regeneration.[9]

References

Further reading

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