MMP25

Matrix metalloproteinase-25 is an enzyme that in humans is encoded by the MMP25 gene.^[4][5][6]

AliasesMMP25, MMP-25, MMP20, MMP20A, MMPL1, MT-MMP 6, MT-MMP6, MT6-MMP, MT6MMP, MTMMP6, matrix metallopeptidase 25

External IDsOMIM: 608482; MGI: 2443938; HomoloGene: 23375; GeneCards: MMP25; OMA:MMP25 - orthologs

Chr.Chromosome 17 (mouse)^[1]

End23,864,251 bp^[1]

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MMP25
Identifiers
Aliases	MMP25, MMP-25, MMP20, MMP20A, MMPL1, MT-MMP 6, MT-MMP6, MT6-MMP, MT6MMP, MTMMP6, matrix metallopeptidase 25
External IDs	OMIM: 608482; MGI: 2443938; HomoloGene: 23375; GeneCards: MMP25; OMA:MMP25 - orthologs
Gene location (Mouse) Chr. Chromosome 17 (mouse)[1] Band 17|17 A3.3 Start 23,847,285 bp[1] End 23,864,251 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in blood spleen vena cava olfactory bulb sperm periodontal fiber appendix body of tongue cervix epithelium bone marrow Top expressed in granulocyte epiblast bone marrow trigeminal ganglion embryo embryo morula tail of embryo thymus neural tube More reference expression data BioGPS More reference expression data
Gene ontology Molecular function zinc ion binding peptidase activity metalloendopeptidase activity hydrolase activity metallopeptidase activity metal ion binding Cellular component integral component of membrane extracellular region anchored component of membrane membrane plasma membrane specific granule membrane extracellular matrix extracellular space Biological process inflammatory response hard palate development proteolysis neutrophil degranulation extracellular matrix organization collagen catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 64386 240047 Ensembl n/a ENSMUSG00000023903 UniProt Q9NPA2 Q3U435 RefSeq (mRNA) NM_004142 NM_022468 NM_022718 NM_001033339 NM_001320258 RefSeq (protein) NP_071913 NP_001028511 NP_001307187 Location (UCSC) n/a Chr 17: 23.85 – 23.86 Mb PubMed search [2] [3]
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Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins that are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily, attached to the plasma membrane via a glycosylphosphatidyl inositol anchor. In response to bacterial infection or inflammation, the encoded protein is thought to inactivate alpha-1 proteinase inhibitor, a major tissue protectant against proteolytic enzymes released by activated neutrophils, facilitating the transendothelial migration of neutrophils to inflammatory sites. The encoded protein may also play a role in tumor invasion and metastasis through activation of MMP2. The gene has previously been referred to as MMP20 but has been renamed MMP25.^[6]