MOAP1

Modulator of apoptosis 1 is a protein that in humans is encoded by the MOAP1 gene.^[5][6]

AliasesMOAP1, MAP-1, PNMA4, modulator of apoptosis 1

External IDsOMIM: 609485; MGI: 1915555; HomoloGene: 11154; GeneCards: MOAP1; OMA:MOAP1 - orthologs

Chr.Chromosome 14 (human)^[1]

End93,184,923 bp^[1]

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MOAP1
Identifiers
Aliases	MOAP1, MAP-1, PNMA4, modulator of apoptosis 1
External IDs	OMIM: 609485; MGI: 1915555; HomoloGene: 11154; GeneCards: MOAP1; OMA:MOAP1 - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q32.12 Start 93,182,199 bp[1] End 93,184,923 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12|12 E Start 102,708,489 bp[2] End 102,709,920 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in superior frontal gyrus prefrontal cortex Brodmann area 9 primary visual cortex right frontal lobe hypothalamus anterior cingulate cortex cerebellum cerebellar cortex cerebellar hemisphere Top expressed in spermatocyte spermatid neural tube testicle mesencephalon hypothalamus dentate gyrus of hippocampal formation granule cell tail of embryo ganglionic eminence Cortex of frontal lobe More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding ubiquitin protein ligase binding Cellular component cytoplasm mitochondrial outer membrane cytosol mitochondrion Biological process apoptotic process apoptotic signaling pathway positive regulation of release of cytochrome c from mitochondria protein insertion into mitochondrial membrane involved in apoptotic signaling pathway extrinsic apoptotic signaling pathway via death domain receptors intrinsic apoptotic signaling pathway in response to DNA damage extrinsic apoptotic signaling pathway in absence of ligand positive regulation of apoptotic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 64112 64113 Ensembl ENSG00000165943 ENSG00000278268 ENSMUSG00000096458 UniProt Q96BY2 Q9ERH6 RefSeq (mRNA) NM_022151 NM_001142937 NM_022323 RefSeq (protein) NP_071434 NP_001136409 NP_071718 Location (UCSC) Chr 14: 93.18 – 93.18 Mb Chr 12: 102.71 – 102.71 Mb PubMed search [3] [4]
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The protein encoded by this gene was identified by its interaction with apoptosis regulator BAX protein. This protein contains a Bcl-2 homology 3 (BH3)-like motif, which is required for the association with BAX. When overexpressed, this gene has been shown to mediate caspase-dependent apoptosis.^[6]