MPP1

55 kDa erythrocyte membrane protein is a protein that in humans is encoded by the MPP1 gene.^[5][6]

PDBOrtholog search: PDBe RCSB

AliasesMPP1, AAG12, DXS552E, EMP55, MRG1, PEMP, membrane palmitoylated protein 1, MAGUK p55 scaffold protein 1

External IDsOMIM: 305360; MGI: 105941; HomoloGene: 1826; GeneCards: MPP1; OMA:MPP1 - orthologs

Chr.X chromosome (human)^[1]

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MPP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2EJY, 2EV8, 3NEY
Identifiers
Aliases	MPP1, AAG12, DXS552E, EMP55, MRG1, PEMP, membrane palmitoylated protein 1, MAGUK p55 scaffold protein 1
External IDs	OMIM: 305360; MGI: 105941; HomoloGene: 1826; GeneCards: MPP1; OMA:MPP1 - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xq28 Start 154,778,684 bp[1] End 154,821,007 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X A7.3|X 38.15 cM Start 74,153,339 bp[2] End 74,174,622 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte blood jejunal mucosa trabecular bone bone marrow bone marrow cell duodenum right lung spleen granulocyte Top expressed in fetal liver hematopoietic progenitor cell tibiofemoral joint blood jejunum ileum right kidney stroma of bone marrow granulocyte endothelial cell of lymphatic vessel white adipose tissue More reference expression data BioGPS More reference expression data
Gene ontology Molecular function guanylate kinase activity protein binding Cellular component cortical cytoskeleton cell projection integral component of plasma membrane intracellular anatomical structure membrane stereocilium cytosol plasma membrane nuclear speck Biological process regulation of neutrophil chemotaxis signal transduction GDP metabolic process GMP metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4354 17524 Ensembl ENSG00000130830 ENSMUSG00000031402 UniProt Q00013 P70290 RefSeq (mRNA) NM_001166460 NM_001166461 NM_001166462 NM_002436 NM_008621 RefSeq (protein) NP_001159932 NP_001159933 NP_001159934 NP_002427 NP_032647 Location (UCSC) Chr X: 154.78 – 154.82 Mb Chr X: 74.15 – 74.17 Mb PubMed search [3] [4]
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Palmitoylated membrane protein 1 is the prototype of a family of membrane-associated proteins termed MAGUKs (membrane-associated guanylate kinase homologs). MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and intracellular junctions. Palmitoylated membrane protein 1 contains a conserved sequence, called the SH3 (src homology 3) motif, found in several other proteins that associate with the cytoskeleton and are suspected to play important roles in signal transduction.^[6]