MQ02-439
Pharmaceutical compound
From Wikipedia, the free encyclopedia
MQ02-439, also known as 1-methoxynoraporphine, is a serotonin 5-HT2C receptor agonist of the noraporphine family.[1] It is a potent and selective full agonist of the serotonin 5-HT2C receptor, with an EC50 (Emax) of 103 nM (96%).[1] The drug showed no activation of the serotonin 5-HT2A and 5-HT2C receptors at concentrations of up to 10,000 nM.[1] However, it did show weak antagonism of these two receptors.[1] The chemical synthesis of MQ02-439 has been described.[1] Various analogues of MQ02-439 have also been described, including some with potent serotonin 5-HT2A receptor agonist activity.[1][2][3] The (S)- enantiomer of MQ02-439 is known as MQ02-592 and is the more potent enantiomer in terms of serotonin 5-HT2C receptor agonism.[1] MQ02-439 was described in the scientific literature by Qi Mao and colleagues in 2020.[1]
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| Other names | 1-Methoxynoraporphine; Compound 18b |
| Drug class | Serotonin 5-HT2C receptor agonist |
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| Formula | C17H17NO |
| Molar mass | 251.329 g·mol−1 |
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