Mitochondrial ribosomal protein L37

39S ribosomal protein L37, mitochondrial is a protein that in humans is encoded by the MRPL37 gene.^[5][6]

PDBOrtholog search: PDBe RCSB

AliasesMRPL37, L37mt, MRP-L2, MRP-L37, MRPL2, RPML2, mitochondrial ribosomal protein L37, L2mt

External IDsOMIM: 611843; MGI: 1926268; HomoloGene: 9536; GeneCards: MRPL37; OMA:MRPL37 - orthologs

Chr.Chromosome 1 (human)^[1]

Quick facts MRPL37, Available structures ...

MRPL37
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3J7Y, 3J9M
Identifiers
Aliases	MRPL37, L37mt, MRP-L2, MRP-L37, MRPL2, RPML2, mitochondrial ribosomal protein L37, L2mt
External IDs	OMIM: 611843; MGI: 1926268; HomoloGene: 9536; GeneCards: MRPL37; OMA:MRPL37 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p32.3 Start 54,184,041 bp[1] End 54,225,464 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 C7 Start 106,913,071 bp[2] End 106,924,065 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastrocnemius muscle muscle of thigh right adrenal gland skin of arm right adrenal cortex tibialis anterior muscle left ventricle right lobe of liver left adrenal gland apex of heart Top expressed in genital tubercle tail of embryo muscle of thigh right kidney ventricular zone embryo lip skeletal muscle tissue embryo triceps brachii muscle More reference expression data BioGPS n/a
Gene ontology Molecular function structural constituent of ribosome RNA binding Cellular component mitochondrial inner membrane ribosome mitochondrial ribosome mitochondrial large ribosomal subunit mitochondrion Biological process mitochondrial translational elongation mitochondrial translational termination protein biosynthesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51253 56280 Ensembl ENSG00000116221 ENSMUSG00000028622 UniProt Q9BZE1 Q921S7 RefSeq (mRNA) NM_016491 NM_001330602 NM_025500 RefSeq (protein) NP_001317531 NP_057575 NP_079776 Location (UCSC) Chr 1: 54.18 – 54.23 Mb Chr 4: 106.91 – 106.92 Mb PubMed search [3] [4]
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Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein.^[6]