Mitochondrial ribosomal protein L41

39S ribosomal protein L41, mitochondrial is a protein that in humans is encoded by the MRPL41 gene.^[5][6]

PDBOrtholog search: PDBe RCSB

AliasesMRPL41, BMRP, MRP-L27, MRPL27, RPML27, PIG3, Mitochondrial ribosomal protein L41

External IDsOMIM: 611846; MGI: 1333816; HomoloGene: 13036; GeneCards: MRPL41; OMA:MRPL41 - orthologs

Chr.Chromosome 9 (human)^[1]

Quick facts MRPL41, Available structures ...

MRPL41
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3J7Y, 3J9M
Identifiers
Aliases	MRPL41, BMRP, MRP-L27, MRPL27, RPML27, PIG3, Mitochondrial ribosomal protein L41
External IDs	OMIM: 611846; MGI: 1333816; HomoloGene: 13036; GeneCards: MRPL41; OMA:MRPL41 - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q34.3 Start 137,551,879 bp[1] End 137,552,555 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 A3 Start 24,864,129 bp[2] End 24,865,110 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart myocardium of left ventricle right auricle of heart right ventricle mucosa of transverse colon cingulate gyrus anterior cingulate cortex caudate nucleus putamen muscle of thigh Top expressed in facial motor nucleus fossa condyle motor neuron epithelium of lens endocardial cushion external carotid artery internal carotid artery renal corpuscle atrioventricular junction More reference expression data BioGPS More reference expression data
Gene ontology Molecular function structural constituent of ribosome protein binding RNA binding Cellular component mitochondrial inner membrane ribosome mitochondrion mitochondrial large ribosomal subunit ribonucleoprotein complex Biological process cell cycle mitochondrial translational elongation mitochondrial translational termination protein biosynthesis apoptotic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 64975 107733 Ensembl ENSG00000182154 ENSMUSG00000036850 UniProt Q8IXM3 Q9CQN7 RefSeq (mRNA) NM_032477 NM_001031808 RefSeq (protein) NP_115866 NP_001026978 Location (UCSC) Chr 9: 137.55 – 137.55 Mb Chr 2: 24.86 – 24.87 Mb PubMed search [3] [4]
Wikidata
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Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the YmL27 ribosomal protein family.^[6]