MS-377
Sigma-1 receptor antagonist
From Wikipedia, the free encyclopedia
MS-377 is a selective antagonist of the sigma-1 receptor.[3] It possesses anti-psychotic properties.
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| Names | |
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| IUPAC name
(3R)-1-(4-Chlorophenyl)-3-[[4-(2-methoxyethyl)piperazin-1-yl]methyl]pyrrolidin-2-one | |
| Identifiers | |
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3D model (JSmol) |
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| ChemSpider | |
PubChem CID |
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| Properties | |
| C18H26ClN3O2 | |
| Molar mass | 351.88 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Properties
MS-377 acts selectively at the sigma-1 receptor as an antagonist. It does not act on dopamine or serotonin receptors unlike most anti-psychotics. Tests have shown that MS-377 could displace ligand binding from the sigma-1 receptor, but did this not happen at the sigma-2, 5-HT2 and D2 receptors, suggesting that it is selective for the sigma-1 receptor.[4]
Despite not acting at serotonin and dopamine receptors, it still affects those monoamine systems. It has been shown that MS-377 reduced the release of serotonin and dopamine induced by PCP.[5] It has also been shown to decrease methamphetamine behavioral sensitization,[6] this is also observed with other sigma antagonists.[7]