MTCH2

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

Mitochondrial carrier homolog 2 also known as MTCH2 is a protein which in humans is encoded by the MTCH2 gene.[5][6][7][8]

AliasesMTCH2, MIMP, SLC25A50, HSPC032, mitochondrial carrier 2
End47,642,607 bp[1]
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MTCH2
Identifiers
AliasesMTCH2, MIMP, SLC25A50, HSPC032, mitochondrial carrier 2
External IDsOMIM: 613221; MGI: 1929260; HomoloGene: 8645; GeneCards: MTCH2; OMA:MTCH2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_014342
NM_001317231
NM_001317232
NM_001317233

NM_019758
NM_001317241
NM_001317242
NM_001317243
NM_001317244

RefSeq (protein)

NP_001304160
NP_001304161
NP_001304162
NP_055157

NP_001304170
NP_001304171
NP_001304172
NP_001304173
NP_062732

Location (UCSC)Chr 11: 47.62 – 47.64 MbChr 2: 90.68 – 90.7 Mb
PubMed search[3][4]
Wikidata
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MTCH2 resides on the outer mitochondrial membrane where it co-localizes with the apoptotic Bcl-2 family protein BID.[9]

Clinical significance

MTCH2 assists in the recruitment of BID into the mitochondria during apoptosis.[9]

Variants of the MTCH2 gene may be associated with obesity.[10] MTCH2 represses mitochondrial metabolism such that a deficiency of MTCH2 increases energy consumption and production by mitochondria.[9]

See also

References

Further reading

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