MTERF1

Mitochondrial transcription termination factor 1, also known as MTERF1, is a protein which in humans is encoded by the MTERF gene.^[5][6][7][8]

PDBOrtholog search: PDBe RCSB

AliasesMTERF1, MTERF, mitochondrial transcription termination factor 1

External IDsOMIM: 602318; MGI: 3704243; HomoloGene: 5073; GeneCards: MTERF1; OMA:MTERF1 - orthologs

Chr.Chromosome 7 (human)^[1]

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MTERF1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3MVA, 3MVB, 3N6S, 3N7Q, 5CO0, 5CRJ, 5CKY, 5CRK
Identifiers
Aliases	MTERF1, MTERF, mitochondrial transcription termination factor 1
External IDs	OMIM: 602318; MGI: 3704243; HomoloGene: 5073; GeneCards: MTERF1; OMA:MTERF1 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q21.2 Start 91,692,008 bp[1] End 91,880,702 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5 A1|5 Start 4,242,367 bp[2] End 4,247,651 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in corpus callosum testicle Achilles tendon lymph node endometrium islet of Langerhans white blood cell monocyte gonad ventricular zone Top expressed in zygote secondary oocyte bone marrow granulocyte morula embryo epiblast embryo tail of embryo primary oocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding protein binding double-stranded DNA binding RNA binding Cellular component mitochondrial matrix mitochondrial nucleoid mitochondrion cytosol Biological process termination of mitochondrial transcription mitochondrion organization regulation of transcription, DNA-templated transcription, DNA-templated DNA geometric change DNA-templated transcription, termination Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7978 208595 Ensembl ENSG00000127989 ENSMUSG00000053178 UniProt Q99551 B9EJ57 RefSeq (mRNA) NM_001301134 NM_001301135 NM_006980 NM_001042670 RefSeq (protein) NP_001288063 NP_001288064 NP_008911 NP_001036135 Location (UCSC) Chr 7: 91.69 – 91.88 Mb Chr 5: 4.24 – 4.25 Mb PubMed search [3] [4]
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This gene encodes a mitochondrial transcription termination factor. This protein participates in attenuating transcription from the mitochondrial genome; this attenuation allows higher levels of expression of 16S ribosomal RNA relative to the tRNA gene downstream. The product of this gene has three leucine zipper motifs bracketed by two basic domains that are all required for DNA binding. There is evidence that, for this protein, the zippers participate in intramolecular interactions that establish the three-dimensional structure required for DNA binding.^[5]