MTF1

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

Metal regulatory transcription factor 1 is a protein that in humans is encoded by the MTF1 gene.[5][6]

AliasesMTF1, MTF-1, ZRF, metal-regulatory transcription factor 1, metal regulatory transcription factor 1
End37,859,592 bp[1]
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MTF1
Identifiers
AliasesMTF1, MTF-1, ZRF, metal-regulatory transcription factor 1, metal regulatory transcription factor 1
External IDsOMIM: 600172; MGI: 101786; HomoloGene: 4347; GeneCards: MTF1; OMA:MTF1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005955

NM_008636

RefSeq (protein)

NP_005946

NP_032662

Location (UCSC)Chr 1: 37.81 – 37.86 MbChr 4: 124.7 – 124.74 Mb
PubMed search[3][4]
Wikidata
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Function

This gene encodes a transcription factor that induces expression of metallothioneins and other genes involved in metal homeostasis in response to heavy metals such as cadmium, zinc, copper, and silver. The protein is a nucleocytoplasmic shuttling protein that accumulates in the nucleus upon heavy metal exposure and binds to promoters containing a metal-responsive element (MRE).[6]

References

Further reading

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