MYBL2

The protein encoded by this gene, a member of the MYB family of transcription factor genes, is a nuclear protein involved in cell cycle progression. The encoded protein is phosphorylated by cyclin A/cyclin-dependent kinase 2 during the S-phase of the cell cycle and possesses both activator and repressor activities. It has been shown to activate the cell division cycle 2, cyclin D1, and insulin-like growth factor-binding protein 5 genes. Transcript variants may exist for this gene, but their full-length natures have not been determined.^[6] MYBL2 is deregulated in various cancer types and can contribute to cancer progression.^[7][8]

MYBL2 has been shown to interact with:

• CDK9^[9]
• CREB-binding protein^[10]
• Cyclin A1^[11]
• Cyclin-dependent kinase inhibitor 1C^[12]
• EP300^[13]
• PARP1^[14]
• Retinoblastoma-like protein 1^[12][15]