MYH14

Myosin-14 is a protein that in humans is encoded by the MYH14 gene.^[5][6][7]

PDBOrtholog search: PDBe RCSB

AliasesMYH14, DFNA4, DFNA4A, MHC16, MYH17, NMHC II-C, NMHC-II-C, PNMHH, myosin, FP17425, myosin, heavy chain 14, non-muscle, myosin heavy chain 14

External IDsOMIM: 608568; MGI: 1919210; HomoloGene: 23480; GeneCards: MYH14; OMA:MYH14 - orthologs

Chr.Chromosome 19 (human)^[1]

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MYH14
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5JLH
Identifiers
Aliases	MYH14, DFNA4, DFNA4A, MHC16, MYH17, NMHC II-C, NMHC-II-C, PNMHH, myosin, FP17425, myosin, heavy chain 14, non-muscle, myosin heavy chain 14
External IDs	OMIM: 608568; MGI: 1919210; HomoloGene: 23480; GeneCards: MYH14; OMA:MYH14 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.33 Start 50,188,186 bp[1] End 50,310,542 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 B3 Start 44,255,227 bp[2] End 44,320,267 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon mucosa of ileum gastrocnemius muscle skin of leg skin of abdomen apex of heart muscle of thigh olfactory zone of nasal mucosa minor salivary glands tibialis anterior muscle Top expressed in corneal stroma saccule superior surface of tongue left colon duodenum right lung gallbladder right lung lobe crypt of lieberkuhn of small intestine ileum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding calmodulin binding actin filament binding microfilament motor activity actin binding cytoskeletal motor activity ATP binding ATPase activity microtubule motor activity microtubule binding Cellular component cytoplasm cytosol myosin II filament membrane growth cone myelin sheath stress fiber axon brush border myosin II complex actomyosin extracellular exosome myosin complex Biological process skeletal muscle contraction actomyosin structure organization hearing actin filament-based movement vocalization behavior regulation of cell shape mitochondrion morphogenesis skeletal muscle tissue development neuronal action potential microtubule-based movement Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 79784 71960 Ensembl ENSG00000105357 ENSMUSG00000030739 UniProt Q7Z406 Q6URW6 RefSeq (mRNA) NM_001077186 NM_001145809 NM_024729 NM_001271538 NM_001271540 NM_028021 RefSeq (protein) NP_001070654 NP_001139281 NP_079005 NP_001258467 NP_001258469 NP_082297 Location (UCSC) Chr 19: 50.19 – 50.31 Mb Chr 7: 44.26 – 44.32 Mb PubMed search [3] [4]
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This gene encodes a member of the myosin superfamily. Myosins are actin-dependent motor proteins with diverse functions, including regulation of cytokinesis, cell motility, and cell polarity. Mutations in this gene result in one form of autosomal dominant hearing impairment. Multiple transcript variants encoding different isoforms have been found for this gene.^[7]