MYL6

Myosin light polypeptide 6 is a protein that in humans is encoded by the MYL6 gene.^[5][6][7][8]

AliasesMYL6, ESMLC, LC17, LC17-GI, LC17-NM, LC17A, LC17B, MLC-3, MLC1SM, MLC3NM, MLC3SM, myosin light chain 6

External IDsOMIM: 609931; MGI: 109318; HomoloGene: 69080; GeneCards: MYL6; OMA:MYL6 - orthologs

Chr.Chromosome 12 (human)^[1]

End56,163,496 bp^[1]

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MYL6
Identifiers
Aliases	MYL6, ESMLC, LC17, LC17-GI, LC17-NM, LC17A, LC17B, MLC-3, MLC1SM, MLC3NM, MLC3SM, myosin light chain 6
External IDs	OMIM: 609931; MGI: 109318; HomoloGene: 69080; GeneCards: MYL6; OMA:MYL6 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q13.2 Start 56,158,346 bp[1] End 56,163,496 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 D3 Start 128,326,729 bp[2] End 128,330,014 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in muscle layer of sigmoid colon popliteal artery tibial arteries left coronary artery right coronary artery ascending aorta Descending thoracic aorta mucosa of transverse colon gastric mucosa body of uterus Top expressed in granulocyte dentate gyrus of hippocampal formation granule cell right kidney lip superior frontal gyrus yolk sac neural layer of retina ventricular zone primary visual cortex spermatocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding structural constituent of muscle cytoskeletal motor activity protein binding Cellular component vesicle cytosol unconventional myosin complex extracellular exosome membrane brush border myosin complex extracellular matrix Biological process muscle contraction skeletal muscle tissue development muscle filament sliding Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4637 17904 Ensembl ENSG00000092841 ENSMUSG00000090841 UniProt P60660 Q60605 RefSeq (mRNA) NM_079425 NM_021019 NM_079423 NM_010860 NM_001317217 NM_001317218 NM_001317219 NM_001317220 RefSeq (protein) NP_066299 NP_524147 NP_001304146 NP_001304147 NP_001304148 NP_001304149 NP_034990 Location (UCSC) Chr 12: 56.16 – 56.16 Mb Chr 10: 128.33 – 128.33 Mb PubMed search [3] [4]
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Myosin is a hexameric ATPase cellular motor protein. It is composed of two heavy chains, two nonphosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene encodes a myosin alkali light chain that is expressed in smooth muscle and non-muscle tissues. Genomic sequences representing several pseudogenes have been described and two transcript variants encoding different isoforms have been identified for this gene.^[8]