MYO18B

Myosin-XVIIIb is a protein that in humans is encoded by the MYO18B gene.^[5][6][7]

AliasesMYO18B, KFS4, myosin XVIIIB

External IDsOMIM: 607295; MGI: 1921626; HomoloGene: 53435; GeneCards: MYO18B; OMA:MYO18B - orthologs

Chr.Chromosome 22 (human)^[1]

End26,031,045 bp^[1]

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MYO18B
Identifiers
Aliases	MYO18B, KFS4, myosin XVIIIB
External IDs	OMIM: 607295; MGI: 1921626; HomoloGene: 53435; GeneCards: MYO18B; OMA:MYO18B - orthologs
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q12.1 Start 25,742,144 bp[1] End 26,031,045 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 F Start 112,836,742 bp[2] End 113,044,228 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart gastrocnemius muscle muscle of thigh Skeletal muscle tissue of rectus abdominis left ventricle Skeletal muscle tissue of biceps brachii right auricle of heart quadriceps femoris muscle vastus lateralis muscle right ventricle Top expressed in muscle of thigh esophagus spermatid lip skeletal muscle tissue lens embryo quadriceps femoris muscle superior frontal gyrus heart More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding actin binding cytoskeletal motor activity ATP binding microtubule motor activity microtubule binding Cellular component cytoplasm unconventional myosin complex sarcomere nucleus myosin complex Z discdkac filamentous actin Biological process microtubule-based movement vasculogenesis in utero embryonic development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 84700 74376 Ensembl ENSG00000133454 ENSMUSG00000072720 UniProt Q8IUG5 n/a RefSeq (mRNA) NM_032608 NM_001318245 NM_028901 RefSeq (protein) NP_001305174 NP_115997 n/a Location (UCSC) Chr 22: 25.74 – 26.03 Mb Chr 5: 112.84 – 113.04 Mb PubMed search [3] [4]
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The protein encoded by this gene may regulate muscle-specific genes when in the nucleus and may influence intracellular trafficking when in the cytoplasm. The encoded protein functions as a homodimer and may interact with F actin. Mutations in this gene are associated with lung cancer.^[7]