Myosin-IIIa

Myosin-IIIa is a protein that in humans is encoded by the MYO3A gene.^[5][6]

AliasesMYO3A, myosin IIIA, DFNB30

External IDsOMIM: 606808; MGI: 2183924; HomoloGene: 49486; GeneCards: MYO3A; OMA:MYO3A - orthologs

Chr.Chromosome 10 (human)^[1]

End26,212,532 bp^[1]

Quick facts MYO3A, Identifiers ...

MYO3A
Identifiers
Aliases	MYO3A, myosin IIIA, DFNB30
External IDs	OMIM: 606808; MGI: 2183924; HomoloGene: 49486; GeneCards: MYO3A; OMA:MYO3A - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10p12.1 Start 25,934,229 bp[1] End 26,212,532 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 A3 Start 22,232,314 bp[2] End 22,508,264 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in islet of Langerhans testicle gonad sperm ventricular zone right testis left testis ganglionic eminence epithelium of colon popliteal artery Top expressed in morula embryo embryo zygote secondary oocyte tail of embryo blastocyst spermatid duodenum superior frontal gyrus More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity protein kinase activity nucleotide binding ADP binding calmodulin binding kinase activity microfilament motor activity protein serine/threonine kinase activity plus-end directed microfilament motor activity actin binding cytoskeletal motor activity ATP binding protein binding Cellular component filamentous actin filopodium cytoskeleton myosin complex cytoplasm stereocilium tip stereocilium filopodium tip cell projection Biological process phosphorylation response to stimulus protein phosphorylation protein autophosphorylation visual perception hearing cochlea morphogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 53904 667663 Ensembl ENSG00000095777 ENSMUSG00000025716 UniProt Q8NEV4 Q8K3H5 RefSeq (mRNA) NM_017433 NM_001368265 NM_148413 RefSeq (protein) NP_059129 NP_001355194 n/a Location (UCSC) Chr 10: 25.93 – 26.21 Mb Chr 2: 22.23 – 22.51 Mb PubMed search [3] [4]
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The protein encoded by this gene belongs to the myosin superfamily. Myosins are actin-dependent motor proteins and are categorized into conventional myosins (class II) and unconventional myosins (classes I and III through XV) based on their variable C-terminal cargo-binding domains. Class III myosins, such as this one, have a kinase domain N-terminal to the conserved N-terminal motor domains and are expressed in photoreceptors. The protein encoded by this gene plays an important role in hearing in humans. Three different recessive, loss of function mutations in the encoded protein have been shown to cause nonsyndromic progressive hearing loss. Expression of this gene is highly restricted, with the strongest expression in retina and cochlea.^[6]